Phenotypes for Clec1b MGI:4839042 MGI Mouse

lethality throughout fetal growth and development, incomplete penetrance ( J:165898 )

• fewer than expected mice are found at E15.5

neonatal lethality, complete penetrance ( J:165898 )

• most mice die shortly after birth with only 2 of 326 mice surviving longer

abnormal lymphatic vessel morphology ( J:165898 )

• lymphatic vessels contain blood cells unlike in wild-type mice

• lymphatic vessels exhibit a dilated, tortuous, and rugged appearance unlike in wild-type mice

• at E14.5 and E17.5, anastomotic sites of blood and lymphatic vessels are observed unlike in wild-type mice

abnormal lymphatic system physiology ( J:165898 )

• mice exhibit defects in lymphatic drainage compared with wild-type mice

abnormal blood vessel morphology ( J:165898 )

• at E14.5 and E17.5, anastomotic sites of blood and lymphatic vessels are observed unlike in wild-type mice

hemorrhage ( J:165898 )

• at E12.5 to E13.5, mice exhibit cutaneous hemorrhage unlike wild-type mice

abnormal platelet activation ( J:165898 )

• platelets from chimeric mice generated using fetal liver transplantation fail to exhibit rhodocytin-induced activation unlike wild-type cells

• however, platelet adhesion and spreading on a surface coated with collage, fibrinogen, laminin, and vWF are normal

decreased platelet aggregation ( J:165898 )

• platelets from chimeric mice generated using fetal liver transplantation exhibit impaired stable thrombus formation under flow conditions and in vivo compared with wild-type cells