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Phenotypes Associated with This Genotype
Genotype
MGI:4838758
Allelic
Composition
Tg(Tagln-rtTA)E1Jwst/0
Tg(tetO-Bmpr2*R899X)#Jwst/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tagln-rtTA)E1Jwst mutation (1 available)
Tg(tetO-Bmpr2*R899X)#Jwst mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• doxycycline-treated mice exhibit pulmonary vascular pruning as determined by microangiography and decreased perfusion of pulmonary vasculature that worsens as right ventricular systolic pressure increases compared to in wild-type mice
• doxycycline-treated mice develop pulmonary vascular lesions with some vessels filled with well-organized layers of smooth muscle and other vessels filled with endothelial unlike in wild-type mice
• muscular lesions in doxycycline-treated mice are associated with macrophages, T cells, and CD133+ cells unlike in wild-type mice
• after 9 weeks of doxycycline treatment, mice exhibit small vessels filled with CD45+ cells unlike in wild-type mice
• however, pulmonary vasculature is present
• corresponding to increased right ventricular systolic pressure in doxycycline-treated mice
• in doxycycline-treated mice

growth/size/body
• in doxycycline-treated mice

respiratory system
• doxycycline-treated mice exhibit pulmonary vascular pruning as determined by microangiography and decreased perfusion of pulmonary vasculature that worsens as right ventricular systolic pressure increases compared to in wild-type mice
• doxycycline-treated mice develop pulmonary vascular lesions with some vessels filled with well-organized layers of smooth muscle and other vessels filled with endothelial unlike in wild-type mice
• muscular lesions in doxycycline-treated mice are associated with macrophages, T cells, and CD133+ cells unlike in wild-type mice
• after 9 weeks of doxycycline treatment, mice exhibit small vessels filled with CD45+ cells unlike in wild-type mice
• however, pulmonary vasculature is present

Mouse Models of Human Disease
OMIM ID Ref(s)
Pulmonary Hypertension, Primary, 1; PPH1 178600 J:164503


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory