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Phenotypes Associated with This Genotype
Genotype
MGI:4838089
Allelic
Composition
Ass1bar/Ass1bar
Genetic
Background
B6.BAR-Ass1bar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ass1bar mutation (0 available); any Ass1 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body

behavior/neurological
• unstable gait (J:165341)
• unstable gait (J:165341)

homeostasis/metabolism
• P14 and P21 mice show a 10- to 40-fold increase in the levels of citrulline, and a 1.5- to threefold increase in the plasma levels of many amino acids, including glutamine, cystine, methionine, and lysine and lysine and arginine, glutamic acid, leucine, and ornithine levels are decreased (J:165341)
• P14 and P21 mice show a 10- to 40-fold increase in the levels of citrulline, and a 1.5- to threefold increase in the plasma levels of many amino acids, including glutamine, cystine, methionine, and lysine and lysine and arginine, glutamic acid, leucine, and ornithine levels are decreased (J:165341)
• Plasma ammonia concentration at P14 is elevated (J:165341)
• Plasma ammonia concentration at P14 is elevated (J:165341)
• argininosuccinate synthetase 1 activity is significantly decreased in liver (J:165341)
• argininosuccinate synthetase 1 activity is significantly decreased in liver (J:165341)

nervous system
• granule cell migration appears to be delayed by several days (J:165341)
• granule cell migration appears to be delayed by several days (J:165341)
• show disorganization and low density and shortening (J:165341)
• show disorganization and low density and shortening (J:165341)

integument
• generalized during first 3 weeks of life (J:165341)
• generalized during first 3 weeks of life (J:165341)
• follicular dystrophy (J:165341)
• follicular dystrophy (J:165341)

cellular
• granule cell migration appears to be delayed by several days (J:165341)
• granule cell migration appears to be delayed by several days (J:165341)

Mouse Models of Human Disease
OMIM ID Ref(s)
Citrullinemia, Classic 215700 J:165341


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory