Phenotypes Associated with This Genotype

Genotype
MGI:4838022

• Allelic Composition: Cacna1b^tm2.1Dili/Cacna1b^tm2.1Dili
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal single cell response ( J:165258 )

• voltage-independent inhibition by DAMGO is reduced in nociceptors compared to in wild-type mice

• however, mice exhibit normal calcium current densities in dorsal root ganglion (DRG) neurons, N-type current densities in DRG neurons, DAMGO inhibition of N-type currents in nociceptors

behavior/neurological

decreased chemically-elicited antinociception ( J:165258 )

• morphine is 30% less effective as an analgesic with reduced effectiveness at all time points compared with similarly treated wild-type mice

• mice exhibit decreased morphine-induced analgesia at high doses compared with wild-type mice