Phenotypes Associated with This Genotype

Genotype
MGI:4838021

• Allelic Composition: Cacna1b^tm1.1Dili/Cacna1b^tm1.1Dili
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:165258 )

• fewer than expected mice are produced

nervous system

abnormal single cell response ( J:165258 )

• dorsal root ganglia neurons exhibit reduced calcium current densities and N-type current densities compared to in wild-type cells

• however, DAMGO inhibition of N-type currents and voltage-independent inhibition in nociceptors are normal

behavior/neurological

behavior/neurological phenotype ( J:165258 )

N • mice exhibit normal analgesic response to morphine