Mouse Genome Informatics
cn
    Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu

involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival of majority of mice is 10-20 weeks after intrabursal injection of an adenovirus expressing Cre

tumorigenesis
• 43% of ovarian tumors metastasize to the lungs
• 7 weeks after intrabursal injection through the infundibulum of an adenovirus expressing Cre, mice, mutants develop endometrioid ovarian cancer
• primary tumor is located in the ovary
• tumors are solid and cystic and diagnosed as ovarian edometrioid adenocarcinomas

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Cancer 167000 J:96296