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Phenotypes Associated with This Genotype
Genotype
MGI:4836596
Allelic
Composition
Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 7 weeks after intrabursal injection through the infundibulum of an adenovirus expressing Cre, mice, mutants develop endometrioid ovarian cancer
• primary tumor is located in the ovary
• tumors are solid and cystic and diagnosed as ovarian edometrioid adenocarcinomas

mortality/aging
• survival of majority of mice is 10-20 weeks after intrabursal injection of an adenovirus expressing Cre

neoplasm
• 43% of ovarian tumors metastasize to the lungs
• 7 weeks after intrabursal injection through the infundibulum of an adenovirus expressing Cre, mice, mutants develop endometrioid ovarian cancer
• primary tumor is located in the ovary
• tumors are solid and cystic and diagnosed as ovarian edometrioid adenocarcinomas

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Cancer 167000 J:96296


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory