Mouse Genome Informatics
hm
    Serpina6tm1.1Mmp/Serpina6tm1.1Mmp
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mice exhibit normal behavior in an elevated plus maze and open field (J:164345)
• cocaine-treated mice fail to exhibit a locomotor response sensitization unlike similarly treated wild-type mice
• during sessions of inescapable footshock, mice exhibit increased learned helplessness escape failures and increased learned helplessness avoidance compared with similarly treated wild-type mice
• in a forced-swim test, mice exhibit increased level of immobility compared with similarly treated wild-type mice

homeostasis/metabolism
• morning, but not evening, concentrations of free corticosterone is greater than in wild-type mice
• stressed mice exhibit decreased free plasma corticosterone compared with similarly treated wild-type mice
• however, total corticosterone levels are normal

Mouse Models of Human Disease
OMIM IDRef(s)
Corticosteroid-Binding Globulin Deficiency 611489 J:164345 , J:192931