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Phenotypes Associated with This Genotype
Genotype
MGI:4833684
Allelic
Composition
Serpina6tm1.1Mmp/Serpina6tm1.1Mmp
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpina6tm1.1Mmp mutation (0 available); any Serpina6 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal behavior in an elevated plus maze and open field
• cocaine-treated mice fail to exhibit a locomotor response sensitization unlike similarly treated wild-type mice
• during sessions of inescapable footshock, mice exhibit increased learned helplessness escape failures and increased learned helplessness avoidance compared with similarly treated wild-type mice
• in a forced-swim test, mice exhibit increased level of immobility compared with similarly treated wild-type mice

homeostasis/metabolism
• morning, but not evening, concentrations of free corticosterone is greater than in wild-type mice
• stressed mice exhibit decreased free plasma corticosterone compared with similarly treated wild-type mice
• however, total corticosterone levels are normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
corticosteroid-binding globulin deficiency DOID:0090030 OMIM:611489
J:164345 , J:192931


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory