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Phenotypes Associated with This Genotype
Genotype
MGI:4833684
Allelic
Composition
Serpina6tm1.1Mmp/Serpina6tm1.1Mmp
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal behavior in an elevated plus maze and open field (J:164345)
• mice exhibit normal behavior in an elevated plus maze and open field (J:164345)
• cocaine-treated mice fail to exhibit a locomotor response sensitization unlike similarly treated wild-type mice (J:164345)
• cocaine-treated mice fail to exhibit a locomotor response sensitization unlike similarly treated wild-type mice (J:164345)
• during sessions of inescapable footshock, mice exhibit increased learned helplessness escape failures and increased learned helplessness avoidance compared with similarly treated wild-type mice (J:164345)
• in a forced-swim test, mice exhibit increased level of immobility compared with similarly treated wild-type mice (J:164345)
• during sessions of inescapable footshock, mice exhibit increased learned helplessness escape failures and increased learned helplessness avoidance compared with similarly treated wild-type mice (J:164345)
• in a forced-swim test, mice exhibit increased level of immobility compared with similarly treated wild-type mice (J:164345)

homeostasis/metabolism
• morning, but not evening, concentrations of free corticosterone is greater than in wild-type mice (J:164345)
• stressed mice exhibit decreased free plasma corticosterone compared with similarly treated wild-type mice (J:164345)
• however, total corticosterone levels are normal (J:164345)
• morning, but not evening, concentrations of free corticosterone is greater than in wild-type mice (J:164345)
• stressed mice exhibit decreased free plasma corticosterone compared with similarly treated wild-type mice (J:164345)
• however, total corticosterone levels are normal (J:164345)

Mouse Models of Human Disease
OMIM ID Ref(s)
Corticosteroid-Binding Globulin Deficiency 611489 J:164345 , J:192931


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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory