Phenotypes Associated with This Genotype

Genotype
MGI:4830995

• Allelic Composition: Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion

nervous system

nervous system phenotype ( J:133358 )

N • mice exhibit normal systemic physiological variables, absolute resting cerebral blood flow, and circle of Willis anatomy

increased susceptibility to ischemic brain injury ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion, mice exhibit increased ischemic lesions size, more pronounced neurological deficits, a larger area of cerebral blood flow deficits, absent transient hypoperfusion episodes, and increased mortality compared with similarly treated wild-type mice

increased cerebral infarct size ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion, ischemic lesions are twice as large as in similarly treated wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:133358 )

N • mice exhibit normal systemic physiological variables, absolute resting cerebral blood flow, and circle of Willis anatomy

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion, mice exhibit increased ischemic lesions size, more pronounced neurological deficits, a larger area of cerebral blood flow deficits, absent transient hypoperfusion episodes, and increased mortality compared with similarly treated wild-type mice

increased cerebral infarct size ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion, ischemic lesions are twice as large as in similarly treated wild-type mice