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Phenotypes Associated with This Genotype
Genotype
MGI:4830676
Allelic
Composition
Scn1btm1.1Bion/Scn1b+
Genetic
Background
Not Specified
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• when exposed to a stream of warm air, mice exhibit febrile seizures (including behavioral arrest, facial automatisms, and early epileptiform discharges localized to the hippocampus) unlike similarly treated wild-type mice (J:163771)
• mice exhibit febrile seizures at lower temperatures than wild-type mice (J:163771)
• when exposed to a stream of warm air, mice exhibit febrile seizures (including behavioral arrest, facial automatisms, and early epileptiform discharges localized to the hippocampus) unlike similarly treated wild-type mice (J:163771)
• mice exhibit febrile seizures at lower temperatures than wild-type mice (J:163771)
• average burst duration in subicular pyramidal neurons is lengthened compared to in wild-type cells (J:163771)
• neurons exhibit axonal hyperexcitability, increased spike gain, and increased burst firing compared with wild-type cells (J:163771)
• however, total burst events and frequency of action potentials within bursts is normal (J:163771)
• average burst duration in subicular pyramidal neurons is lengthened compared to in wild-type cells (J:163771)
• neurons exhibit axonal hyperexcitability, increased spike gain, and increased burst firing compared with wild-type cells (J:163771)
• however, total burst events and frequency of action potentials within bursts is normal (J:163771)
• the number of action potentials (APs) per bursts is increased compared to in wild-type mice (J:163771)
• neurons begin firing APs at lower drive currents compared to in wild-type mice (J:163771)
• the threshold for AP initiation is more negative than in wild-type cells (J:163771)
• the amplitude of first APs is higher than in wild-type cells (J:163771)
• the AP half-width is decreased compared to in wild-type cells (J:163771)
• however, the frequency of action potentials within bursts is normal (J:163771)
• the number of action potentials (APs) per bursts is increased compared to in wild-type mice (J:163771)
• neurons begin firing APs at lower drive currents compared to in wild-type mice (J:163771)
• the threshold for AP initiation is more negative than in wild-type cells (J:163771)
• the amplitude of first APs is higher than in wild-type cells (J:163771)
• the AP half-width is decreased compared to in wild-type cells (J:163771)
• however, the frequency of action potentials within bursts is normal (J:163771)

behavior/neurological
• mice exhibit febrile seizures at lower temperatures than wild-type mice (J:163771)
• when exposed to a stream of warm air, mice exhibit febrile seizures (including behavioral arrest, facial automatisms, and early epileptiform discharges localized to the hippocampus) unlike similarly treated wild-type mice (J:163771)
• when exposed to a stream of warm air, mice exhibit febrile seizures (including behavioral arrest, facial automatisms, and early epileptiform discharges localized to the hippocampus) unlike similarly treated wild-type mice (J:163771)
• mice exhibit febrile seizures at lower temperatures than wild-type mice (J:163771)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory