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Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
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phenotype observed in females
phenotype observed in males
N normal phenotype
• mean survival is 495 days compared to 632 days for wild-type mice

nervous system
• at 6 months, hippocampus volume is decreased compared to in wild-type mice
• at 6 months
• at 6 months, ubiquitin+ inclusions are detected in the neurons unlike in wild-type cells
• however, no inclusions are observed at 2 months
• cortical neurons are reduced in number compared to in wild-type mice
• at 6 months, mice exhibit neuronal loss that resembles frontotemporal lobar degeneration with ubiquitin+ inclusions unlike wild-type mice
• at 2 months, mice exhibit decreased miniature excitatory postsynaptic current (mEPSC) amplitude and altered decay kinetics compared to in wild-type mice

• at 2 and 6 months, mice exhibit impaired 1-hour novel object recognition compared with wild-type mice
• at 2 months, mice exhibit impaired performance in a Morris water maze compared to wild-type mice
• at 6 months, mice develop progressive motor behavioral deficits unlike wild-type mice
• at 6 months
• at 6 months on a rotarod


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory