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Phenotypes Associated with This Genotype
Genotype
MGI:4830521
Allelic
Composition
Tg(Camk2a-Tardbp)#Ckjs/Tg(Camk2a-Tardbp)#Ckjs
Genetic
Background
FVB/N-Tg(Camk2a-Tardbp)#Ckjs
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival is 495 days compared to 632 days for wild-type mice

nervous system
• at 6 months, hippocampus volume is decreased compared to in wild-type mice
• at 6 months
• at 6 months, ubiquitin+ inclusions are detected in the neurons unlike in wild-type cells
• however, no inclusions are observed at 2 months
• cortical neurons are reduced in number compared to in wild-type mice
• at 6 months, mice exhibit neuronal loss that resembles frontotemporal lobar degeneration with ubiquitin+ inclusions unlike wild-type mice
• at 2 months, mice exhibit decreased miniature excitatory postsynaptic current (mEPSC) amplitude and altered decay kinetics compared to in wild-type mice

behavior/neurological
• at 2 and 6 months, mice exhibit impaired 1-hour novel object recognition compared with wild-type mice
• at 2 months, mice exhibit impaired performance in a Morris water maze compared to wild-type mice
• at 6 months, mice develop progressive motor behavioral deficits unlike wild-type mice
• at 6 months
• at 6 months on a rotarod

cellular


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory