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Phenotypes Associated with This Genotype
Genotype
MGI:4830468
Allelic
Composition
Ank2tm1Bnt/Ank2+
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank2tm1Bnt mutation (1 available); any Ank2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in isoproterenol-treated mice
• isoproterenol-treated mice exhibit disorganized shifts of the leading pacemaker and competing multiple pacemakers compared with similarly treated wild-type mice
• acetylcholine-treated mice exhibit reduced sensitivity of pacemaker function compared with similarly treated wild-type mice

homeostasis/metabolism
• isoproterenol-treated mice exhibit increased heart rate variability, a larger beat-to-beat variability, disorganized shifts of the leading pacemaker, and competing multiple pacemakers compared with similarly treated wild-type mice
• acetylcholine-treated mice exhibit reduced sensitivity of pacemaker function compared with similarly treated wild-type mice

adipose tissue
• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.
• decreased basal adipocyte glucose uptake
• however, insulin-stimulated uptake is normal

cellular
• mouse embryonic fibroblasts exhibit increased adipogenesis with both increased in adipocyte numbers and enlarged lipid droplets compared with wild-type cells.
• decreased basal adipocyte glucose uptake
• however, insulin-stimulated uptake is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
sinoatrial node disease DOID:0050824 J:163867


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory