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Phenotypes Associated with This Genotype
Genotype
MGI:4829692
Allelic
Composition
Myh9tm2(GFP/MYH10)Rsad/Myh9tm2(GFP/MYH10)Rsad
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh9tm2(GFP/MYH10)Rsad mutation (1 available); any Myh9 mutation (218 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
N
• unlike null mice, knock in embryos undergo gastrulation
• fewer visible vessels at E9.5 and E10.5
• display growth retardation that becomes more pronounced with age
• placentas are composed predominantly of clusters of cuboidal trophoblasts
• the spongiotrophoblast layer is difficult to discern
• the labyrinth layer is difficult to discern
• embryonic blood vessels fail to invade the labyrinth layer
• thinner and more compact compared to controls
• at E9.5 and E10.5

cardiovascular system
• the vascular network is less intricate at E10.5
• embryonic blood vessels fail to invade the labyrinth layer
• the vascular networks of the head and trunk are less intricate at E10.5
• fewer visible vessels at E9.5 and E10.5

cellular
• in MEFs actin filaments are thin, disorganized and often fail to align with the direction of migration
• fewer and smaller focal adhesions are detected in MEFs and the stress fibers in the focal adhesions are in disarray
• in a wound healing assay MEFs close the wound more rapidly compared to wild-type controls
• a transwell assay indicates that directional cell migration is impaired in MEFs

growth/size/body
• display growth retardation that becomes more pronounced with age

nervous system
• the vascular network is less intricate at E10.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory