Mouse Genome Informatics
hm
    Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
involves: 129S2/SvPas * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 5 of 11 mice die unexpectedly around 15 weeks

hematopoietic system
• the number of nucleated cells in the femur is decreased with an increase in neutrophil precursors (1.5)-fold and a reduction in erythroblasts (2-fold) and lymphocytes (3-fold)
• circulating granulocyte precursors (myeloblasts and metamyelocytes) are observed unlike in wild-type mice
• myeloid precursors are increased 82-fold in the spleen compared to in wild-type mice
• CFU-GM (colony forming unit-granulocyte-macrophage) progenitor cells are increased 4-fold
• erythroblasts are observed unlike in wild-type mice
• erythroid precursors are increased 88-fold in the spleen compared to in wild-type mice
• CFU-E (cumulative colony forming unit) progenitor cells are increased 87-fold
• BFU-E (colony forming unit-erythroid) progenitor cells are increased 6-fold
• 3-fold with giant platelets
• mice exhibit megakaryocytic hyperplasia compared with wild-type mice
• mice develop spleen fibrosis with low collagen deposition unlike wild-type mice
• over time due to an accumulation of erythroid (88-fold) and myeloid (82-fold) precursor without a blockage of maturation

homeostasis/metabolism

immune system
• mice develop spleen fibrosis with low collagen deposition unlike wild-type mice
• over time due to an accumulation of erythroid (88-fold) and myeloid (82-fold) precursor without a blockage of maturation

Mouse Models of Human Disease
OMIM IDRef(s)
Myelofibrosis 254450 J:163497
Polycythemia Vera; PV 263300 J:163497
NOT Thrombocythemia 1; THCYT1 187950 J:163497