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Phenotypes Associated with This Genotype
Genotype
MGI:4829588
Allelic
Composition
Jak2tm1.1Jlvl/Jak2tm1.1Jlvl
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.1Jlvl mutation (0 available); any Jak2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 5 of 11 mice die unexpectedly around 15 weeks (J:163497)
• 5 of 11 mice die unexpectedly around 15 weeks (J:163497)

hematopoietic system
• in the liver (J:163497)
• in the liver (J:163497)
• the number of nucleated cells in the femur is decreased with an increase in neutrophil precursors (1.5)-fold and a reduction in erythroblasts (2-fold) and lymphocytes (3-fold) (J:163497)
• the number of nucleated cells in the femur is decreased with an increase in neutrophil precursors (1.5)-fold and a reduction in erythroblasts (2-fold) and lymphocytes (3-fold) (J:163497)
• circulating granulocyte precursors (myeloblasts and metamyelocytes) are observed unlike in wild-type mice (J:163497)
• myeloid precursors are increased 82-fold in the spleen compared to in wild-type mice (J:163497)
• CFU-GM (colony forming unit-granulocyte-macrophage) progenitor cells are increased 4-fold (J:163497)
• circulating granulocyte precursors (myeloblasts and metamyelocytes) are observed unlike in wild-type mice (J:163497)
• myeloid precursors are increased 82-fold in the spleen compared to in wild-type mice (J:163497)
• CFU-GM (colony forming unit-granulocyte-macrophage) progenitor cells are increased 4-fold (J:163497)
• mice exhibit megakaryocytic hyperplasia compared with wild-type mice (J:163497)
• mice exhibit megakaryocytic hyperplasia compared with wild-type mice (J:163497)
• erythroblasts are observed unlike in wild-type mice (J:163497)
• erythroid precursors are increased 88-fold in the spleen compared to in wild-type mice (J:163497)
• CFU-E (cumulative colony forming unit) progenitor cells are increased 87-fold (J:163497)
• BFU-E (colony forming unit-erythroid) progenitor cells are increased 6-fold (J:163497)
• erythroblasts are observed unlike in wild-type mice (J:163497)
• erythroid precursors are increased 88-fold in the spleen compared to in wild-type mice (J:163497)
• CFU-E (cumulative colony forming unit) progenitor cells are increased 87-fold (J:163497)
• BFU-E (colony forming unit-erythroid) progenitor cells are increased 6-fold (J:163497)
• doubled (J:163497)
• doubled (J:163497)
• 4.7-fold (J:163497)
• 4.7-fold (J:163497)
• 3-fold with giant platelets (J:163497)
• 3-fold with giant platelets (J:163497)
• 7.3-fold (J:163497)
• 7.3-fold (J:163497)
• 12.5-fold (J:163497)
• 12.5-fold (J:163497)
• 3.3-fold (J:163497)
• 3.3-fold (J:163497)
• 3.5-fold (J:163497)
• 3.5-fold (J:163497)
• mice develop spleen fibrosis with low collagen deposition unlike wild-type mice (J:163497)
• mice develop spleen fibrosis with low collagen deposition unlike wild-type mice (J:163497)
• over time due to an accumulation of erythroid (88-fold) and myeloid (82-fold) precursor without a blockage of maturation (J:163497)
• over time due to an accumulation of erythroid (88-fold) and myeloid (82-fold) precursor without a blockage of maturation (J:163497)

homeostasis/metabolism

immune system
• 7.3-fold (J:163497)
• 7.3-fold (J:163497)
• 12.5-fold (J:163497)
• 12.5-fold (J:163497)
• 3.3-fold (J:163497)
• 3.3-fold (J:163497)
• 3.5-fold (J:163497)
• 3.5-fold (J:163497)
• mice develop spleen fibrosis with low collagen deposition unlike wild-type mice (J:163497)
• mice develop spleen fibrosis with low collagen deposition unlike wild-type mice (J:163497)
• over time due to an accumulation of erythroid (88-fold) and myeloid (82-fold) precursor without a blockage of maturation (J:163497)
• over time due to an accumulation of erythroid (88-fold) and myeloid (82-fold) precursor without a blockage of maturation (J:163497)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory