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Phenotypes Associated with This Genotype
Genotype
MGI:4822359
Allelic
Composition
Dnm1Ftfl/Dnm1Ftfl
Genetic
Background
C57BL/6J-Dnm1Ftfl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1Ftfl mutation (1 available); any Dnm1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only survive into the second or third week of life

behavior/neurological
• post-natal day 12 (P12) progressive ataxia
• post-natal day 12 (P12) progressive ataxia characterized by an abnormal and uncoordinated stance and gait
• postnatal day 12 (P12) progressive ataxia characterized by an abnormal and uncoordinated stance and gait
• spontaneous convulsive seizures that usually result in death before weaning age
• seizures at P14-P16, a seizure episode typically lasts 30 seconds to one minute and is immediately followed by a clear diminishment in health and movement.

nervous system
• spontaneous convulsive seizures that usually result in death before weaning age
• seizures at P14-P16, a seizure episode typically lasts 30 seconds to one minute and is immediately followed by a clear diminishment in health and movement.
• Purkinje cell dendritic trees are markedly smaller in all homozygous mice examined at P17

hearing/vestibular/ear
• the latencies of most ABR peaks are progressively prolonged
• the amplitude of some of the ABR peaks are reduced in the mutants
• display a modest ABR threshold increase, approximately 15 dB, across all sound frequencies tested

Mouse Models of Human Disease
OMIM ID Ref(s)
Epilepsy, Idiopathic Generalized; EIG 600669 J:163311


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory