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Phenotypes Associated with This Genotype
Genotype
MGI:4820821
Allelic
Composition
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0
Genetic
Background
FVB/N-Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• distorted architecture with lymphoid follicles in disarray

cellular
• increased B220+, Ki67+ immunohistochemical staining

hematopoietic system
• exhibit an increased number of atypical lymphoid cells and numerous malignant lymphoid cells
• expanded CD5+ B-cell population in spleen, peripheral blood and bone marrow
• distorted architecture with lymphoid follicles in disarray
• mice show impaired immune response in production of anti-sheep RBC (SRBC) antibodies after injection of SRBC
• increased B220+, Ki67+ immunohistochemical staining

immune system
• exhibit an increased number of atypical lymphoid cells and numerous malignant lymphoid cells
• expanded CD5+ B-cell population in spleen, peripheral blood and bone marrow
• distorted architecture with lymphoid follicles in disarray
• mice show impaired immune response in production of anti-sheep RBC (SRBC) antibodies after injection of SRBC
• increased B220+, Ki67+ immunohistochemical staining

neoplasm
• 50% CD5+CD19+IgM+ B cells shows clonal rearrangements of the IgH gene in three of five cases analyzed


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory