Phenotypes Associated with This Genotype

Genotype
MGI:4820803

• Allelic Composition: Ret^tm2.1Heno/Ret^tm2.1Heno
• Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

absent kidney ( J:135153 )

nervous system

increased neuron apoptosis ( J:135153 )

• many apoptotic figures are observed in the foregut of E10.5

abnormal enteric nervous system morphology ( J:135153 )

• no enteric nervous system precursors at E12.5

cellular

increased neuron apoptosis ( J:135153 )

• many apoptotic figures are observed in the foregut of E10.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Hirschsprung's disease		DOID:10487	OMIM:600156 OMIM:606874 OMIM:606875 OMIM:608462 OMIM:611644	J:135153