Phenotypes Associated with This Genotype

Genotype
MGI:4819864

• Allelic Composition: Tg(CEACAM5-Tag)L5496Wzm/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:62581 )

• become moribund by 100 - 130 days of age due to blockage of the pylorus by the tumor mass

neoplasm

increased gastric adenocarcinoma incidence ( J:62581 )

• all develop gastric carcinomas that are most probably adenocarcinomas

• tumors are visible by 37 days of age and are identified as small dysplastic crypts located within the stomach mucosa in the pyloric region

• by 50 days of age high grade tumors with a focal adenoid growth pattern have already started to invade the submucosa

• tumors eventually block the pylorus and grow into the duodenum

digestive/alimentary system

enlarged cecum ( J:62581 )

enlarged duodenum ( J:62581 )

• duodenum region is often enlarged

increased gastric adenocarcinoma incidence ( J:62581 )

• all develop gastric carcinomas that are most probably adenocarcinomas

• tumors are visible by 37 days of age and are identified as small dysplastic crypts located within the stomach mucosa in the pyloric region

• by 50 days of age high grade tumors with a focal adenoid growth pattern have already started to invade the submucosa

• tumors eventually block the pylorus and grow into the duodenum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
stomach cancer		DOID:10534	OMIM:613659	J:62581