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Phenotypes Associated with This Genotype
Genotype
MGI:4819864
Allelic
Composition
Tg(CEACAM5-Tag)L5496Wzm/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CEACAM5-Tag)L5496Wzm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• become moribund by 100 - 130 days of age due to blockage of the pylorus by the tumor mass

neoplasm
• all develop gastric carcinomas that are most probably adenocarcinomas
• tumors are visible by 37 days of age and are identified as small dysplastic crypts located within the stomach mucosa in the pyloric region
• by 50 days of age high grade tumors with a focal adenoid growth pattern have already started to invade the submucosa
• tumors eventually block the pylorus and grow into the duodenum

digestive/alimentary system
• duodenum region is often enlarged
• all develop gastric carcinomas that are most probably adenocarcinomas
• tumors are visible by 37 days of age and are identified as small dysplastic crypts located within the stomach mucosa in the pyloric region
• by 50 days of age high grade tumors with a focal adenoid growth pattern have already started to invade the submucosa
• tumors eventually block the pylorus and grow into the duodenum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
stomach cancer DOID:10534 OMIM:137215
OMIM:613659
J:62581


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory