Analysis Tools
mortality/aging
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• in an E. coli model of pneumonia, mice exhibit fewer bacteria in the lungs, increased neutrophil infiltration in the lungs, reduced lung wet/dry weight at 24 hours post-infection, decreased edema, and reduced mortality compared with similarly treated wild-type mice
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immune system
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• mice exhibit increased Gr1+ and Gr1+ CXCR2+ cells in the bone marrow compared with wild-type mice
• however, the number of neutrophils in the blood is normal
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• in LPS or E. coli models of pneumonia, initial neutrophil influx into the lungs is enhanced but declines more rapidly than in similarly treated wild-type mice
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• following intatracheal E. coli challenge, mice exhibit reduced CXCL1 and CXCL2 plasma levels while bronchoalveolar fluid levels are increased compared with similarly treated wild-type mice
• after injection with recombinant CXCL1, CXCL2, and CXCL5, mice exhibit attenuated plasma concentrations of these chemokines compared with similarly treated wild-type mice
• after injection with CXCL1, the amount of plasma CXCL1 is decreased with the amount of erythrocyte-binding CXCL1 is increased compared to in wild-type mice
• in response to inhaled LPS, mice exhibit attenuated CXCL1 levels in the plasma compared with similarly treated wild-type mice
• mice exhibit improved chemokine scavenging compared with wild-type mice
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• 6 hours after intatracheal E. coli challenge
• however, levels are normal at 24 hours post infection
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• in response to inhaled LPS, mice exhibit attenuated neutrophil infiltration, TNFalpha and IL6 levels in the bronchoalvealoar fluid, and CXCL1 in the plasma compared with similarly treated wild-type mice
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• in an E. coli model of pneumonia
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• in an E. coli model of pneumonia, mice exhibit fewer bacteria in the lungs, increased neutrophil infiltration in the lungs, reduced lung wet/dry weight at 24 hours post-infection, decreased edema, and reduced mortality compared with similarly treated wild-type mice
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homeostasis/metabolism
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• following intatracheal E. coli challenge, mice exhibit reduced CXCL1 and CXCL2 plasma levels while bronchoalveolar fluid levels are increased compared with similarly treated wild-type mice
• after injection with recombinant CXCL1, CXCL2, and CXCL5, mice exhibit attenuated plasma concentrations of these chemokines compared with similarly treated wild-type mice
• after injection with CXCL1, the amount of plasma CXCL1 is decreased with the amount of erythrocyte-binding CXCL1 is increased compared to in wild-type mice
• in response to inhaled LPS, mice exhibit attenuated CXCL1 levels in the plasma compared with similarly treated wild-type mice
• mice exhibit improved chemokine scavenging compared with wild-type mice
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• 6 hours after intatracheal E. coli challenge
• however, levels are normal at 24 hours post infection
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hematopoietic system
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• mice exhibit increased Gr1+ and Gr1+ CXCR2+ cells in the bone marrow compared with wild-type mice
• however, the number of neutrophils in the blood is normal
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• in LPS or E. coli models of pneumonia, initial neutrophil influx into the lungs is enhanced but declines more rapidly than in similarly treated wild-type mice
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