Phenotypes Associated with This Genotype

Genotype
MGI:4819768

• Allelic Composition: Atxn1^tm1Hzo/Atxn1⁺
• Genetic Background: B6.129S7-Atxn1^tm1Hzo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:119643 , J:177841 )

• mice die before 60 weeks of age (J:119643)

• mice exhibit premature lethality (J:177841)

• however, exercise improves survival (J:177841)

nervous system

decreased Purkinje cell number ( J:119643 , J:177841 )

neuronal intranuclear inclusions ( J:177841 )

behavior/neurological

abnormal associative learning ( J:177841 )

• impaired fear conditioning

ataxia ( J:119643 )

impaired coordination ( J:119643 , J:177841 , J:198661 )

• on a rotarod and dowel test (J:177841)

• mice exhibit increased latency to cross a dowel rod and walk off the rod fewer times than wild-type mice (J:198661)

decreased locomotor activity ( J:177841 )

• in an open field test

growth/size/body

decreased body weight ( J:177841 )