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Phenotypes Associated with This Genotype
Genotype
MGI:4819722
Allelic
Composition
Tg(Myh6-TNNT2*R92Q)#Ajm/0
Genetic
Background
involves: C3H * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no change in survival is detected in mice up to 2 years of age

cardiovascular system
N
• no increase in heart weight is detected
• cardiomyocyte disarray (J:161899)
• cardiomyocyte disarray comprising about 27% of the myocardium compared to about 4% in controls (J:162685)
• decrease in left ventricular end systolic diameters
• increase in the collagen volume fraction (J:161899)
• in 2/3 of 3 to 12 month old mice (J:162685)
• treatment with Losartan significantly reduces interstitial fibrillar collagen (J:162685)
• increase in left ventricular systolic function

muscle
• cardiomyocyte disarray (J:161899)
• cardiomyocyte disarray comprising about 27% of the myocardium compared to about 4% in controls (J:162685)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 2 DOID:0110308 OMIM:115195
J:161899 , J:162685


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory