Mouse Genome Informatics
cn
    Pkd1tm1Gztn/Pkd1tm1Gztn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+

involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
renal/urinary system
• tamoxifen treated mice develop kindey cysts
• however, treatment with Genz-123346 inhibits cystogenesis
• tamoxifen-treated mice exhibit progressive renal function decline over 4 to 5 weeks
• however, treament with Genz-123346 improves kidney fucntion

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:162080