About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4819716
Allelic
Composition
Pkd1tm1Gztn/Pkd1tm1Gztn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (305 available)
Pkd1tm1Gztn mutation (0 available); any Pkd1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• tamoxifen treated mice develop kindey cysts (J:162080)
• however, treatment with Genz-123346 inhibits cystogenesis (J:162080)
• tamoxifen treated mice develop kindey cysts (J:162080)
• however, treatment with Genz-123346 inhibits cystogenesis (J:162080)
• tamoxifen-treated mice exhibit progressive renal function decline over 4 to 5 weeks (J:162080)
• however, treament with Genz-123346 improves kidney fucntion (J:162080)
• tamoxifen-treated mice exhibit progressive renal function decline over 4 to 5 weeks (J:162080)
• however, treament with Genz-123346 improves kidney fucntion (J:162080)

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 1; PKD1 173900 J:162080


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory