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Phenotypes Associated with This Genotype
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Kcnj11*V59M)Fmas mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• mice, especially females, are born at less than Mendelian frequency

• trend towards lower body weight

• impaired balance control at 12 weeks of age
• take three times longer than controls to turn around on a thin rod suspended above the ground, and many fell off while attempting to do so
• fall off a rotating rod earlier than control mice at 12 weeks of age
• unable to hang as long from an inverted screen or a horizontal bar at 12 weeks of age
• more spontaneous activities than controls at 12 weeks of age
• stay significantly longer than controls in free-running wheels at 12 weeks of age
• run longer distance over a 23-hour period on a free-running wheel

nervous system
• more hyperpolarized resting membrane potential of cerebellar Purkinje cells in acute brain slices than in controls
• restored by tolbutamide, a specific inhibitor of KATP channels
• substantially lower action potential frequency of cerebellar Purkinje cells in acute brain slices in both cell-attached and whole-cell recordings
• restored by tolbutamide
• the ATP sensitivity of the native muscle ATP-sensitive potassium (KATP) channel is reduced compared with that of control mice in patch-clamp recordings of isolated muscle fibers

• unable to lift weights as effectively or to hang as long from an inverted screen or a horizontal bar at 12 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
permanent neonatal diabetes mellitus DOID:0060639 OMIM:606176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory