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Phenotypes Associated with This Genotype
Genotype
MGI:4818803
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 146 days

neoplasm
• all develop a myeloproliferative neoplasm
• these myeloproliferative neoplasms can be transplanted by transfer of either unfractionated bone marrow cells or LSK cells but not by transfer of MEP or granulocyte/macrophage progenitor cells
• however, acute leukemia is not detected

hematopoietic system
N
• despite the increase in megakaryocyte numbers no increases in platelet counts are detected
• expansion of the megakaryocytic/erythroid progenitor (MEP) population
• disproportional increase in the number of erythroid progenitors relative to other myeloid progenitor
• increase in the number of erythroid precursors in the bone marrow and spleen
• marked erythroid hyperplasia in the splenic red pulp
• prominent splenic extramedullary hematopoiesis
• megakaryocytes with atypical nuclear features and prominent emperipolesis are present in the bone marrow
• mild hyperplasia in the splenic red pulp
• overall effacement of the normal architecture
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp
• MEPs show EPO hypersensitivity
• gene set enrichment analysis indicates that hematopoietic differentiation in the LSK compartment is altered

immune system
• overall effacement of the normal architecture
• marked erythroid and mild megakaryocytic hyperplasia in the splenic red pulp

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycythemia Vera; PV 263300 J:160883


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory