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Phenotypes Associated with This Genotype
Genotype
MGI:4818797
Allelic
Composition
Pdgfratm2Sor/Pdgfratm2Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfratm2Sor mutation (0 available); any Pdgfra mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

muscle
• at E12, some surviving mice exhibit little to no diaphragm formation unlike wild-type mice
• at E12, some surviving mice exhibit delayed closure of bilateral posterior pleuroperitoneal folds unlike wild-type mice
• 2 of 7 mice exhibit open posterior pleuroperitoneal folds with variable herniation of the stomach into the thorax unlike wild-type mice

respiratory system

cardiovascular system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital diaphragmatic hernia DOID:3827 OMIM:142340
OMIM:222400
OMIM:610187
J:160875


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory