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Phenotypes Associated with This Genotype
Genotype
MGI:4818797
Allelic
Composition
Pdgfratm2Sor/Pdgfratm2Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfratm2Sor mutation (0 available); any Pdgfra mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die before E10 (J:160875)
• 50% of mice die before E10 (J:160875)

muscle
• at E12, some surviving mice exhibit little to no diaphragm formation unlike wild-type mice (J:160875)
• at E12, some surviving mice exhibit little to no diaphragm formation unlike wild-type mice (J:160875)
• at E12, some surviving mice exhibit delayed closure of bilateral posterior pleuroperitoneal folds unlike wild-type mice (J:160875)
• 2 of 7 mice exhibit open posterior pleuroperitoneal folds with variable herniation of the stomach into the thorax unlike wild-type mice (J:160875)
• at E12, some surviving mice exhibit delayed closure of bilateral posterior pleuroperitoneal folds unlike wild-type mice (J:160875)
• 2 of 7 mice exhibit open posterior pleuroperitoneal folds with variable herniation of the stomach into the thorax unlike wild-type mice (J:160875)

respiratory system

cardiovascular system

Mouse Models of Human Disease
OMIM ID Ref(s)
Diaphragmatic Hernia, Congenital 142340 J:160875


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory