Phenotypes Associated with This Genotype

Genotype
MGI:4818469

• Allelic Composition: Sgms2^tm1Jia/Sgms2^tm1Jia
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:162192 )

• plasma ApoE levels are increased in mice fed a high-fat diet compared to in similarly treated wild-type mice

abnormal lipid level ( J:162192 , J:162226 )

• plasma levels of ceramide, sphingosine, and sphingosine-1-phosphate are increased compared to in wild-type mice (J:162192)

• sphingosine-1-phosphate levels in the liver are decreased compared to in wild-type mice (J:162192)

• however, total cholesterol, phospholipids and triglyceride levels are normal (J:162192)

• the amount of diacyglycerol in macrophages is decreased while the amount of ceramide in macrophages is increased compared to in wild-type cells (J:162226)

• however, the level of phosphatidylcholine is normal (J:162226)

abnormal sphingomyelin level ( J:162192 )

• plasma levels of sphingomyelin (SM) and HDL-SM are decreased compared to in wild-type mice

• liver SM levels are decreased compared to in wild-type mice

• mice fed a high cholesterol diet exhibit a decrease in plasma SM (HDL and non-HDL) levels compared with similarly treated wild-type mice

hematopoietic system

abnormal macrophage morphology ( J:162226 )

• the amount of diacyglycerol in macrophages is decreased while the amount of ceramide in macrophages is increased compared to in wild-type cells

• however, the level of phosphatidylcholine is normal

hemolysis ( J:162192 )

• red blood cells are less sensitive to lysenin-mediated cytolysis compared with wild-type cells

abnormal macrophage physiology ( J:162192 , J:162226 )

• macrophages are less sensitive to lysenin-mediated cytolysis compared with wild-type cells (J:162192)

• macrophages are less sensitive to lysenin-mediated cytolysis compared with wild-type cells (J:162226)

immune system

abnormal macrophage morphology ( J:162226 )

• the amount of diacyglycerol in macrophages is decreased while the amount of ceramide in macrophages is increased compared to in wild-type cells

• however, the level of phosphatidylcholine is normal

abnormal macrophage physiology ( J:162192 , J:162226 )

• macrophages are less sensitive to lysenin-mediated cytolysis compared with wild-type cells (J:162192)

• macrophages are less sensitive to lysenin-mediated cytolysis compared with wild-type cells (J:162226)

liver/biliary system

abnormal hepatocyte physiology ( J:162192 )

• hepatocytes are less sensitive to lysenin-mediated cytolysis than wild-type cells

cellular

abnormal cell physiology ( J:162192 )

• embryo fibroblasts are less sensitive to lysenin-mediated cytolysis compared with wild-type cells