Phenotypes Associated with This Genotype

Genotype
MGI:4462392

• Allelic Composition: Chrna1^tm1Klee/Chrna1^tm1Klee
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:161300 )

nervous system

abnormal innervation pattern to muscle ( J:161300 )

• the number of nerve branches in muscles is increased compared to in wild-type mice

increased motor neuron number ( J:161300 )

abnormal neuromuscular synapse morphology ( J:161300 )

• synaptic contact length and postsynaptic membrane length in the neuromuscular synapses compared to in wild-type mice

abnormal endplate potential ( J:161300 )

• muscles lack nerve-evoked endplate potential unlike wild-type muscles

abnormal miniature endplate potential ( J:161300 )

• absent

behavior/neurological

carpoptosis ( J:161300 )

• at E15.5

skeleton

kyphosis ( J:161300 )

• at E15.5