Phenotypes Associated with This Genotype

Genotype
MGI:4461228

• Allelic Composition: Mkx^tm1Asah/Mkx^tm1Asah
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal tendon morphology ( J:161299 )

• at 3 months, tendons are hypoplastic and pale white in color unlike in wild-type mice

• tensile strength is reduced due to decreased tendon mass compared to in wild-type mice

• at 7 days and 3 months, patellar tendons are thinner than in wild-type mice

• tail tendons contain small tendon fiber bundles and higher cell density compared to in wild-type mice

• however, mice exhibit normal cell number in tail tendon fiber bundles

• tendons contain smaller diameter collagen fibrils compared with wild-type tendons

skeleton

abnormal tendon morphology ( J:161299 )

• at 3 months, tendons are hypoplastic and pale white in color unlike in wild-type mice

• tensile strength is reduced due to decreased tendon mass compared to in wild-type mice

• at 7 days and 3 months, patellar tendons are thinner than in wild-type mice

• tail tendons contain small tendon fiber bundles and higher cell density compared to in wild-type mice

• however, mice exhibit normal cell number in tail tendon fiber bundles

• tendons contain smaller diameter collagen fibrils compared with wild-type tendons