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Phenotypes Associated with This Genotype
Genotype
MGI:4461160
Allelic
Composition
Tnfrsf1atm2.1Rsie/Tnfrsf1a+
Genetic
Background
B6.Cg-Tnfrsf1atm2.1Rsie
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm2.1Rsie mutation (0 available); any Tnfrsf1a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice treated with 5 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice
• Background Sensitivity: mice on a C57BL/6 background are less sensitive to LPS and D-galactosamine than mice on a 129S6 background
• however, mortality at 10 ng/g LPS and D-galactosamine is normal

immune system
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells
• following LPS challenge
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells
• LPS-stimulated mouse embryonic fibroblasts exhibit increased IL6 secretion that is enhanced by application of TNFR2-Fc compared with similarly treated wild-type cells
• mice treated with LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice
• Background Sensitivity: mice on a C57BL/6 background are less sensitive to LPS and D-galactosamine than mice on a 129S6 background
• however, mortality at 10 ng/g LPS and D-galactosamine is normal

homeostasis/metabolism
• following LPS challenge

hematopoietic system
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Periodic Fever, Familial, Autosomal Dominant 142680 J:160543


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory