Mouse Genome Informatics
ht
    Tnfrsf1atm2.1Rsie/Tnfrsf1a+
B6.Cg-Tnfrsf1atm2.1Rsie
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice treated with 5 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice
• Background Sensitivity: mice on a C57BL/6 background are less sensitive to LPS and D-galactosamine than mice on a 129S6 background
• however, mortality at 10 ng/g LPS and D-galactosamine is normal

immune system
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells
• following LPS challenge
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells
• LPS-stimulated mouse embryonic fibroblasts exhibit increased IL6 secretion that is enhanced by application of TNFR2-Fc compared with similarly treated wild-type cells
• mice treated with LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice
• Background Sensitivity: mice on a C57BL/6 background are less sensitive to LPS and D-galactosamine than mice on a 129S6 background
• however, mortality at 10 ng/g LPS and D-galactosamine is normal

homeostasis/metabolism
• following LPS challenge

hematopoietic system
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells

Mouse Models of Human Disease
OMIM IDRef(s)
Periodic Fever, Familial, Autosomal Dominant 142680 J:160543