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Phenotypes Associated with This Genotype
Genotype
MGI:4461136
Allelic
Composition
Tg(Tnf)6074Gkl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnf)6074Gkl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products
• at 8-10 weeks of age some astroglial scarring
• minimal blood-brain barrier damage and immune infiltration can be observed at the meninges at 1 week of age
• at 4 weeks of age pronounced inflammation at the brain meninges
• at 8-10 weeks of age moderate axonal damage is evident within plaques
• at 1 week of age TUNEL+ cells characteristic of apoptosis are found in the corpus callosum
• at 8-10 weeks of age signs of BBB leakage
• oligodendrocyte apoptosis starting at 1 week of age
• T lymphocyte infiltration in the cerebellum at 8-10 weeks of age
• early demyelinating events consisting of myelin swelling and the formation of vacuoles with single fiber degeneration at 4 weeks of age
• by 8-10 weeks of age confluent symmetrical plaques of primary demyelination develop within the cerebellar white matter, the capsula interna and to a minor degree, the optic tracts

hematopoietic system
• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products

immune system
• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products
• T lymphocyte infiltration in the cerebellum at 8-10 weeks of age

cardiovascular system
• at 8-10 weeks of age signs of BBB leakage

cellular
• oligodendrocyte apoptosis starting at 1 week of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
J:106592


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory