Mouse Genome Informatics
tg
    Tg(Tnf)6074Gkl/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products
• at 8-10 weeks of age some astroglial scarring
• minimal blood-brain barrier damage and immune infiltration can be observed at the meninges at 1 week of age
• at 4 weeks of age pronounced inflammation at the brain meninges
• at 1 week of age TUNEL+ cells characteristic of apoptosis are found in the corpus callosum
• at 8-10 weeks of age signs of BBB leakage
• oligodendrocyte apoptosis starting at 1 week of age
• T lymphocyte infiltration in the cerebellum at 8-10 weeks of age
• early demyelinating events consisting of myelin swelling and the formation of vacuoles with single fiber degeneration at 4 weeks of age
• by 8-10 weeks of age confluent symmetrical plaques of primary demyelination develop within the cerebellar white matter, the capsula interna and to a minor degree, the optic tracts
• at 8-10 weeks of age moderate axonal damage is evident within plaques

hematopoietic system
• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products

immune system
• at 1 week of age there is widespread microglial activation
• at 8-10 weeks plaque edge cells contain myelin degradation products
• T lymphocyte infiltration in the cerebellum at 8-10 weeks of age

cardiovascular system
• at 8-10 weeks of age signs of BBB leakage

cellular
• oligodendrocyte apoptosis starting at 1 week of age

Mouse Models of Human Disease
OMIM IDRef(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:106592