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Phenotypes Associated with This Genotype
Genotype
MGI:4460267
Allelic
Composition
Msh2tm2.1Rak/Msh2tm3.1Rak
Tg(Vil-cre)20Syr/0
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm2.1Rak mutation (1 available); any Msh2 mutation (69 available)
Msh2tm3.1Rak mutation (0 available); any Msh2 mutation (69 available)
Tg(Vil-cre)20Syr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• beginning at 10 months, mice develop intestinal tumors
• by 13 months, 50% of mice develop intestinal tumors

neoplasm
• beginning at 10 months, mice develop intestinal tumors
• by 13 months, 50% of mice develop intestinal tumors
• mice develop more and smaller tumors than in Msh2tm1Rak/Msh2tm2.1Wed Tg(Vil-cre)20Syr mice
• tumors respond to treatment with cisplatin or FOLFOX unlike tumors from Msh2tm1Rak/Msh2tm2.1Wed Tg(Vil-cre)20Syr mice

homeostasis/metabolism
• tumor cells exhibit increased microsatellite instability compared with wild-type cells
• tumors respond to treatment with cisplatin or FOLFOX unlike tumors from Msh2tm1Rak/Msh2tm2.1Wed Tg(Vil-cre)20Syr mice
• FOLFOX-treated intestinal mucosa cells exhibit decreased apoptosis compared with similarly treated cells from Msh2tm2.1Wed homozygotes but increased compared with similarly treated cell from Msh2tm1Rak/Msh2tm2.1Wed Tg(Vil-cre)20Syr mice

cellular
• tumor cells exhibit increased microsatellite instability compared with wild-type cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Lynch Syndrome I 120435 J:161577


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory