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Phenotypes Associated with This Genotype
Genotype
MGI:4459523
Allelic
Composition		 Il17rbtm1Lex/Il17rbtm1Lex
Genetic
Background		 C.129-Il17rbtm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rbtm1Lex mutation (3 available); any Il17rb mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal osteoclast differentiation ( J:159874 )
• IL17A or IL17F induced osteoclast differentiation is completely abolished
abnormal chemokine secretion ( J:159874 )
• KC/CXCL1 and G-CSF are not induced by lung fibroblasts or MEFs in response to IL17A or IL17F application
decreased interleukin-5 secretion ( J:159874 )
• IL5 induction is abolished in splenocytes
decreased interleukin-6 secretion ( J:159874 )
• by lung fibroblasts or MEFs in response to IL17A or IL7F application

hematopoietic system
abnormal osteoclast differentiation ( J:159874 )
• IL17A or IL17F induced osteoclast differentiation is completely abolished

skeleton
abnormal osteoclast differentiation ( J:159874 )
• IL17A or IL17F induced osteoclast differentiation is completely abolished

cellular
abnormal osteoclast differentiation ( J:159874 )
• IL17A or IL17F induced osteoclast differentiation is completely abolished

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory