Phenotypes Associated with This Genotype

Genotype
MGI:4459521

• Allelic Composition: Il22^tm1.1Lex/Il22^tm1.1Lex
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:161073 )

• ranged from 80% to 100% in the second week after infection with C. rodentium

immune system

colitis ( J:161073 )

• an increase in submucosal and transmural inflammation after r C. rodentium infection

abnormal circulating cytokine level ( J:179011 )

• reduced levels of CCL3 and CCL4 after Aspergillus fumigatus infection

decreased circulating interleukin-1 alpha level ( J:179011 )

• after Aspergillus fumigatus infection

decreased circulating interleukin-12 level ( J:179011 )

• after Aspergillus fumigatus infection

decreased circulating interleukin-12b level ( J:179011 )

• after Aspergillus fumigatus infection

increased circulating interleukin-17 level ( J:179011 )

• elevated IL-17A after Aspergillus fumigatus infection

decreased circulating tumor necrosis factor level ( J:179011 )

• after Aspergillus fumigatus infection

lung inflammation ( J:179011 )

• develop an 8 fold higher Aspergillus fumigatus burden by 24 hours after Aspergillus fumigatus infection

increased susceptibility to bacterial infection induced morbidity/mortality ( J:161073 )

• ranged from 80% to 100% in the second week after infection with C. rodentium

increased susceptibility to fungal infection ( J:179011 )

• develop an 8 fold higher Aspergillus fumigatus burden by 24 hours after Aspergillus fumigatus infection

growth/size/body

decreased body weight ( J:161073 )

• continue to lose weight after C. rodentium infection

digestive/alimentary system

abnormal large intestine crypts of Lieberkuhn morphology ( J:161073 )

• bacteria penetrate deeply into the colonic crypts after C. rodentium infection

abnormal colon morphology ( J:161073 )

• an increase in mucosal hyperplasia and multiple foci of colonic mucosal ulceration after r C. rodentium infection

colitis ( J:161073 )

• an increase in submucosal and transmural inflammation after r C. rodentium infection

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:161073 )

• bacteria penetrate deeply into the colonic crypts after C. rodentium infection

liver/biliary system

multifocal hepatic necrosis ( J:161073 )

• with embolic microabscessation in the liver following C. rodentium infection

respiratory system

lung inflammation ( J:179011 )

• develop an 8 fold higher Aspergillus fumigatus burden by 24 hours after Aspergillus fumigatus infection

homeostasis/metabolism

abnormal circulating cytokine level ( J:179011 )

• reduced levels of CCL3 and CCL4 after Aspergillus fumigatus infection

decreased circulating interleukin-1 alpha level ( J:179011 )

• after Aspergillus fumigatus infection

decreased circulating interleukin-12 level ( J:179011 )

• after Aspergillus fumigatus infection

decreased circulating interleukin-12b level ( J:179011 )

• after Aspergillus fumigatus infection

increased circulating interleukin-17 level ( J:179011 )

• elevated IL-17A after Aspergillus fumigatus infection

decreased circulating tumor necrosis factor level ( J:179011 )

• after Aspergillus fumigatus infection

cellular

multifocal hepatic necrosis ( J:161073 )

• with embolic microabscessation in the liver following C. rodentium infection