About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4459448
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (61 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• by 6 months, adeno-cre-treated mice exhibit lung tumors unlike wild-type mice
• adeno-cre-treated mice exhibit few lung adenocarcinomas, adenocarcinomas with neuroendocrine features, large-cell neuroendocrine carcinoma, and large-cell carcinomas while most tumors resemble neuroendocrine small-cell lung tumors
• most tumors in adeno-cre-treated mice resemble those found in human neuroendocrine small cell lung cancer patients

mortality/aging
• adeno-cre-treated mice die by 28 week

neoplasm
• by 6 months, adeno-cre-treated mice exhibit lung tumors unlike wild-type mice
• adeno-cre-treated mice exhibit few lung adenocarcinomas, adenocarcinomas with neuroendocrine features, large-cell neuroendocrine carcinoma, and large-cell carcinomas while most tumors resemble neuroendocrine small-cell lung tumors
• most tumors in adeno-cre-treated mice resemble those found in human neuroendocrine small cell lung cancer patients

Mouse Models of Human Disease
OMIM ID Ref(s)
Small Cell Cancer of the Lung 182280 J:160148


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory