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Phenotypes Associated with This Genotype
Genotype
MGI:4459096
Allelic
Composition
Tg(Mbp-Pad2)28Fgm/0
Genetic
Background
involves: CD-1
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• develop convulsions by 1.5 months of age
• in the cerebellum and C1-C5 regions of the spinal cord at 6 months of age
• optic nerves display areas of myelinolysis and thinly myelinated axons
• gene dosage correlated decrease in myelinated fiber density and myelin thickness
• show clinical signs of demyelination (tail droop, shaky gait, head shaking, convulsions, impaired righting response, reduced physical activity) by 1.5 months of age
• signs increase in severity with age but not as rapidly as in homozygous mice

behavior/neurological
• develop tremors by 1.5 months of age
• display proprioceptive positioning defects at 4 months of age
• becomes impaired by 1.5 months of age
• at 4 months of age
• at 4 months of age
• develop tail droop by 1.5 months of age
• develop a shaky gait by 1.5 months of age
• develops by 1.5 months of age
• develop convulsions by 1.5 months of age

homeostasis/metabolism
• increase in the levels in the brain by 4 months of age

immune system
• increase in the levels in the brain by 4 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Multiple Sclerosis, Susceptibility To; MS 126200 J:142650


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory