Analysis Tools
hearing/vestibular/ear
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• mice exhibit normal vestibular function
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• the tectorial membrane is thicker and shorter than in wild-type and heterozygous mice
• the shortened tectorial membrane does not cover all three rows of the outer hair cells unlike in wild-type mice
• the fibrils surrounding the edge of the tectorial membrane are severely disrupted compared to in wild-type mice
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• Kimura's membrane contains severely disrupted fibrils compared to in wild-type mice
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• during acoustic stimulation of the stapes, outer hair cells in all rows exhibit no forward transduction unlike in similarly treated wild-type cells
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• in response to an accoustic stimuli, cochlear microphonic is asymmetrical, reduced in amplitude, and a quarter of a cycle ahead of the stimulus unlike in wild-type mice
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• homozygous mice had 30-50 dB ABR threshold elevations relative to wild-type littermates
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• mice exhibit severe hearing loss compared with wild-type mice
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nervous system
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• during acoustic stimulation of the stapes, outer hair cells in all rows exhibit no forward transduction unlike in similarly treated wild-type cells
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• in response to an accoustic stimuli, cochlear microphonic is asymmetrical, reduced in amplitude, and a quarter of a cycle ahead of the stimulus unlike in wild-type mice
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