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Phenotypes Associated with This Genotype
Genotype
MGI:4457647
Allelic
Composition		 Clcn5tm1Tjj/Y
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clcn5tm1Tjj mutation (0 available); any Clcn5 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased urine insulin level ( J:160701 )
• urine insulin levels are increased compared to in wild-type mice

cellular
abnormal cell physiology ( J:160701 )
• endocytosis is defective compared to in wild-type cells
• renal endosomes fail to undergo acidification unlike in wild-type cells

homeostasis/metabolism
increased urine insulin level ( J:160701 )
• urine insulin levels are increased compared to in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory