Phenotypes Associated with This Genotype

Genotype
MGI:4457409

• Allelic Composition: Slc23a1^tm1Mlev/Slc23a1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:159697 )

• lethargic mice with homozygous dams exhibit the same lethality as homozygotes

• however, maternal supplementation with ascorbate rescues lethality

homeostasis/metabolism

abnormal blood homeostasis ( J:159697 )

• female and male mice exhibit intermediate ascorbate plasma and urine levels compared with wild-type and homozygous mice

abnormal urine homeostasis ( J:159697 )

• female and male mice exhibit intermediate ascorbate plasma and urine levels compared with wild-type and homozygous mice

abnormal vitamin homeostasis ( J:159697 )

• female and male mice exhibit intermediate ascorbate plasma and urine levels compared with wild-type and homozygous mice

• female mice exhibit reduced ascorbate absorption in the heart compared with wild-type mice

• female mice exhibit increased ascorbate absorption in the intestine compared with wild-type mice

abnormal vitamin absorption ( J:159697 )

• female mice exhibit reduced ascorbate absorption in the heart compared with wild-type mice

• mice exhibit intermediate accumulation of an ascorbate analog in the liver compared with wild-type and homozygous mice

• however, intestinal accumulation of an ascorbate analog is normal

behavior/neurological

lethargy ( J:159697 )

• in some mice of homozygous dams

digestive/alimentary system

abnormal vitamin absorption ( J:159697 )

• mice exhibit intermediate accumulation of an ascorbate analog in the liver compared with wild-type and homozygous mice

• female mice exhibit reduced ascorbate absorption in the heart compared with wild-type mice

• however, intestinal accumulation of an ascorbate analog is normal

renal/urinary system

abnormal urine homeostasis ( J:159697 )

• female and male mice exhibit intermediate ascorbate plasma and urine levels compared with wild-type and homozygous mice