Phenotypes Associated with This Genotype

Genotype
MGI:4457066

• Allelic Composition: Irf6^tm1Mjd/Irf6^tm1Mjd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal incisor morphology ( J:184926 )

• enlarged anterior incisors prematurely exposed to oral cavity

• incisor tooth germs lack connective tissue, alveolar bone, oral epithelium and dental lamina

abnormal craniofacial development ( J:184926 )

• at E13.5, surface epithelium exhibits cobblestone-like cells unlike in wild-type mice

abnormal tooth development ( J:184926 )

• incisor epithelium fail to invaginate into the underlying mesenchyme but rather evaginates

failure of palatal shelf elevation ( J:160190 )

• the palate shelves fail to elevate

palatal shelf fusion with tongue or mandible ( J:160190 )

• the palate shelves adhere completely to the tongue

digestive/alimentary system

failure of palatal shelf elevation ( J:160190 )

• the palate shelves fail to elevate

palatal shelf fusion with tongue or mandible ( J:160190 )

• the palate shelves adhere completely to the tongue

growth/size/body

abnormal incisor morphology ( J:184926 )

• enlarged anterior incisors prematurely exposed to oral cavity

• incisor tooth germs lack connective tissue, alveolar bone, oral epithelium and dental lamina

abnormal tooth development ( J:184926 )

• incisor epithelium fail to invaginate into the underlying mesenchyme but rather evaginates

failure of palatal shelf elevation ( J:160190 )

• the palate shelves fail to elevate

palatal shelf fusion with tongue or mandible ( J:160190 )

• the palate shelves adhere completely to the tongue

skeleton

abnormal incisor morphology ( J:184926 )

• enlarged anterior incisors prematurely exposed to oral cavity

• incisor tooth germs lack connective tissue, alveolar bone, oral epithelium and dental lamina

abnormal tooth development ( J:184926 )

• incisor epithelium fail to invaginate into the underlying mesenchyme but rather evaginates