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Phenotypes Associated with This Genotype
Genotype
MGI:4455027
Allelic
Composition
RhoTvrm4/Rho+
Rpe65rd12/Rpe65rd12
Genetic
Background
B6.Cg-Rpe65rd12 RhoTvrm4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm4 mutation (0 available); any Rho mutation (23 available)
Rpe65rd12 mutation (1 available); any Rpe65 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Photoreceptor degeneration without exposure to bright light in Rpe65rd12/Rpe65rd12 RhoTvrm4/Rho+ mice

vision/eye
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina
• at 4 weeks of age, retinas have only 2-3 rows of cell bodies remaining in the central outer nuclear layer

nervous system
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa; RP 268000 J:159523


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory