Mouse Genome Informatics
cx
    RhoTvrm4/Rho+
Rpe65rd12/Rpe65rd12

B6.Cg-Rpe65rd12 RhoTvrm4
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Photoreceptor degeneration without exposure to bright light in Rpe65rd12/Rpe65rd12 RhoTvrm4/Rho+ mice

vision/eye
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina
• at 4 weeks of age, retinas have only 2-3 rows of cell bodies remaining in the central outer nuclear layer

nervous system
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease
OMIM IDRef(s)
Retinitis Pigmentosa; RP 268000 J:159523