About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4455025
Allelic
Composition
RhoTvrm4/Rho+
Genetic
Background
B6.Cg-RhoTvrm4/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm4 mutation (2 available); any Rho mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Light-induced degeneration of photoreceptors in RhoTvrm4/Rho+ mice

homeostasis/metabolism
• extracts of whole eyes collected immediately after exposure to 12,000 lux for 5 mins contain significantly lower levels of all trans-retinol than in wild-type
• however, no difference is detected at 1 h after light exposure
• exposure to 12,000 lux of light for 5 min leads to visible bleaching of the entire retina for 1 h following exposure, in contrast wild-type retinas are unaffected
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration

vision/eye
• TUNEL+ photoreceptors
• exposure to 12,000 lux of light for 5 min leads to visible bleaching of the entire retina for 1 h following exposure, in contrast wild-type retinas are unaffected
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
• slightly shorter at 1 year of age
• 1 h after exposure to 12,000 lux of bright light, appear disorganized and some areas are devoid of outer segments, whereas others appear to contain outer segment aggregates
• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected
• after exposure to 12,000 lux of bright light, apical processes of retinal pigment epithelium that normally ensheath the outer segments appear to extend further along the outer segments than in wild-type
• 24 h after exposure to 12,000 lux of bright light the outer nuclear layer appears disorganized, although cell loss is not apparent
• two or fewer layers of photoreceptor nuclei remaining at 1 week following light exposure
• mice recover with a time constant of 9.5 min and reach an asymptote that is only 60% of the dark adapted value

nervous system
• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
• slightly shorter at 1 year of age
• 1 h after exposure to 12,000 lux of bright light, appear disorganized and some areas are devoid of outer segments, whereas others appear to contain outer segment aggregates
• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected

pigmentation
• after exposure to 12,000 lux of bright light, apical processes of retinal pigment epithelium that normally ensheath the outer segments appear to extend further along the outer segments than in wild-type

cellular
• TUNEL+ photoreceptors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:159523


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2020
MGI 6.15
The Jackson Laboratory