Mouse Genome Informatics
tg
    Tg(Fabp4-LMNA*R482Q)11ACdl/0
FVB-Tg(Fabp4-LMNA*R482Q)11ACdl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• in the subscapular brown adipose fat pad when fed a high fat diet
• after 14 weeks of age when fed a high fat diet
• 59% less at 63 weeks when fed a high fat diet
• after 28 week weeks of age when fed standard chow
• when fed a high fat diet, fat cells exhibit less cell size uniformity compared to in similarly treated wild-type mice
• with unilocular deposition when fed a high fat diet
• leukocyte infiltration when mice are fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet

homeostasis/metabolism
• when fed a high fat diet, mice exhibit altered insulin sensitivity in the liver, muscle, and white adipose tissues compared with similarly treated wild-type mice
• moderately when fed a high fat diet
• in a glucose tolerance test at week 22 when fed a high fat diet
• by week 18 when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet

growth/size/body
• after 14 weeks of age when fed a high fat diet
• 59% less at 63 weeks when fed a high fat diet
• after 28 week weeks of age when fed standard chow
• as a percentage of body weight when fed a high fat diet

muscle
N
• unlike patients with FPLD2, mice do not exhibit robust skeletal muscle hypertrophy (J:149858)
• when fed a high fat diet

cellular
• when fed a high fat diet

Mouse Models of Human Disease
OMIM IDRef(s)
Lipodystrophy, Familial Partial, Type 2; FPLD2 151660 J:149858