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Phenotypes Associated with This Genotype
Genotype
MGI:4454331
Allelic
Composition
Tg(Fabp4-LMNA*R482Q)11ACdl/0
Genetic
Background
FVB-Tg(Fabp4-LMNA*R482Q)11ACdl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Fabp4-LMNA*R482Q)11ACdl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in the subscapular brown adipose fat pad when fed a high fat diet
• after 14 weeks of age when fed a high fat diet
• 59% less at 63 weeks when fed a high fat diet
• after 28 week weeks of age when fed standard chow
• when fed a high fat diet, fat cells exhibit less cell size uniformity compared to in similarly treated wild-type mice
• with unilocular deposition when fed a high fat diet
• leukocyte infiltration when mice are fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet

homeostasis/metabolism
• when fed a high fat diet, mice exhibit altered insulin sensitivity in the liver, muscle, and white adipose tissues compared with similarly treated wild-type mice
• moderately when fed a high fat diet
• in a glucose tolerance test at week 22 when fed a high fat diet
• by week 18 when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet

growth/size/body
• as a percentage of body weight when fed a high fat diet

muscle
N
• unlike patients with FPLD2, mice do not exhibit robust skeletal muscle hypertrophy
• when fed a high fat diet

cellular
• when fed a high fat diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory