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Phenotypes Associated with This Genotype
Genotype
MGI:4454331
Allelic
Composition
Tg(Fabp4-LMNA*R482Q)11ACdl/0
Genetic
Background
FVB-Tg(Fabp4-LMNA*R482Q)11ACdl
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in the subscapular brown adipose fat pad when fed a high fat diet
• after 14 weeks of age when fed a high fat diet
• 59% less at 63 weeks when fed a high fat diet
• after 28 week weeks of age when fed standard chow
• when fed a high fat diet, fat cells exhibit less cell size uniformity compared to in similarly treated wild-type mice
• with unilocular deposition when fed a high fat diet
• leukocyte infiltration when mice are fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet

homeostasis/metabolism
• when fed a high fat diet, mice exhibit altered insulin sensitivity in the liver, muscle, and white adipose tissues compared with similarly treated wild-type mice
• moderately when fed a high fat diet
• in a glucose tolerance test at week 22 when fed a high fat diet
• by week 18 when fed a high fat diet
• when fed a high fat diet
• when fed a high fat diet

growth/size/body
• as a percentage of body weight when fed a high fat diet

muscle
N
• unlike patients with FPLD2, mice do not exhibit robust skeletal muscle hypertrophy
• when fed a high fat diet

cellular
• when fed a high fat diet

Mouse Models of Human Disease
OMIM ID Ref(s)
Lipodystrophy, Familial Partial, Type 2; FPLD2 151660 J:149858


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory