Phenotypes Associated with This Genotype

Genotype
MGI:4452396

• Allelic Composition: Ptch1^tm1Hahn/Ptch1^tm1Hahn; Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased basal cell carcinoma incidence ( J:158915 )

• after 45 days of tamoxifen treatment, mice exhibit visible tumors in the tails and ears unlike similarly treated wild-type mice

• 90 days after tamoxifen treatment, mice exhibit fully developed basal cell carcinomas (BCC) that are not invasive or aggressive over time

• BCCs likely originate from the outer root sheath of the hair follicle based on antibody staining

decreased tumor growth/size ( J:158915 )

• after 200 days of tamoxifen treatment tumors are smaller than fully developed basal cell carcinomas and exhibit decreased proliferation indicating regression

integument

increased basal cell carcinoma incidence ( J:158915 )

• after 45 days of tamoxifen treatment, mice exhibit visible tumors in the tails and ears unlike similarly treated wild-type mice

• 90 days after tamoxifen treatment, mice exhibit fully developed basal cell carcinomas (BCC) that are not invasive or aggressive over time

• BCCs likely originate from the outer root sheath of the hair follicle based on antibody staining

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
basal cell carcinoma		DOID:2513		J:158915