Analysis Tools
mortality/aging
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• fewer than expected mice are born
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behavior/neurological
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• mice exhibit normal general learning and motor function
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• following naloxone-precipitated morphine withdrawal, female mice on the original line with the Oprm1 allele from 129S6/SvEvTac exhibit less jumping than males unlike wild-type or recombinant mice the Oprm1 allele from C57BL/6
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• mice with an Oprm1 allele from 129S6/SvEv exhibit increased sensitivity to morphine analgesia in a tail flick or hot plate test compared with wild-type mice which carried the Oprm1 allele from C57BL/6
• however, a recombinant line with the Oprm1 allele from C57BL/6 exhibit normal analgesic response to morphine
• in a hot plate assay, recombinant mice with an Oprm1 allele from C57BL/6 exhibit faster development of morphine tolerance compared with wild-type mice
• recombinant mice with the Oprm1 allele from C57BL/6 exhibit a rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
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• recombinant mice with the Oprm1 allele from C57BL/6 exhibit a rightward shift in the dose-response curve for morphine conditioned place preference compared with wild-type mice
• however, locomotion in response to increasing morphine dose in recombinant mice with the Oprm1 allele from C57BL/6 is normal
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• mice with an Oprm1 allele from 129S6/SvEv exhibit increased sensitivity to morphine analgesia in a tail flick or hot plate test compared with wild-type mice which carried the Oprm1 allele from C57BL/6
• however, a recombinant line with the mutant allele and the Oprm1 allele from C57BL/6 exhibit normal analgesic response to morphine
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