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Phenotypes Associated with This Genotype
Genotype
MGI:4443011
Allelic
Composition		 Dok1tm1Ppp/Dok1tm1Ppp
Dok3tm1Ppp/Dok3tm1Ppp
Genetic
Background		 129S1/Sv-Dok1tm1Ppp Dok3tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (19 available)
Dok3tm1Ppp mutation (0 available); any Dok3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 51% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

respiratory system
increased lung adenocarcinoma incidence ( J:158011 )
• at 11-25 months, 51% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory