Phenotypes Associated with This Genotype

Genotype
MGI:4442997

• Allelic Composition: Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spectrum of posterior defects in Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc and Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc mice

reproductive system

abnormal genital tubercle morphology ( J:201925 )

• absent

nervous system

abnormal dendritic spine morphology ( J:159217 )

• cultured hippocampal neurons exhibit simpler dendritic arbors, fewer dendritic spines, a reduction in dendrite branch crossings at all distances from the soma, and an increase in the proportion of immature filopodial spines relative to mature spines compared with wild-type neurons

• however, expression of recombinant protein rescues the density of dendritic spines and proportion of mature spines

abnormal synapse morphology ( J:159217 )

• cultured hippocampal neurons exhibit reduced excitatory synapse staining of presynaptic and postsynaptic markers compared with wild-type mice

• however, staining of inhibitory synapse markers is normal

decreased miniature excitatory postsynaptic current frequency ( J:159217 )

• mice exhibit reduced frequency of miniature excitatory postsynaptic currents (mEPSCs) compared with wild-type mice

• however, mEPSC amplitudes are normal

limbs/digits/tail

short tail ( J:201925 )