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Phenotypes Associated with This Genotype
Genotype
MGI:4442806
Allelic
Composition		 Pggt1btm1Mbrg/Pggt1btm1Mbrg
Tg(KRT14-cre)1Amc/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
Tg(KRT14-cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:158528 )
• die within a few hours of birth with little milk in their stomachs

integument
decreased keratinocyte proliferation ( J:158528 )
• epidermal keratinocytes do not proliferate in culture
underdeveloped hair follicles ( J:158528 )
• E19.5 embryos have stunted hair follicles

cellular
decreased keratinocyte proliferation ( J:158528 )
• epidermal keratinocytes do not proliferate in culture

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory