Phenotypes Associated with This Genotype

Genotype
MGI:4442175

• Allelic Composition: Ptprc^ltng/Ptprc^ltng
• Genetic Background: C57BL/6-Ptprc^ltng

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• mice exhibit enhanced negative selection compared with wild-type mice

• positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprc^tm1Mak homozygotes

decreased double-positive T cell number ( J:158876 )

decreased CD4-positive, alpha-beta T cell number ( J:158876 )

• SP4 thymocytes are reduced compared to in wild-type mice

hematopoietic system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• mice exhibit enhanced negative selection compared with wild-type mice

• positive selection of T cell is rescued and single positive thymic subsets compared to in Ptprc^tm1Mak homozygotes

decreased double-positive T cell number ( J:158876 )

decreased CD4-positive, alpha-beta T cell number ( J:158876 )

• SP4 thymocytes are reduced compared to in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:158876 )