Phenotypes Associated with This Genotype

Genotype
MGI:4441317

• Allelic Composition: Adam22^tm1Sag/Adam22^tm1Sag
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:166449 )

• most mice die immediately after birth

nervous system

abnormal glial cell morphology ( J:166449 )

• enteric sections exhibit fewer glial cells than in wild-type mice

abnormal neuron morphology ( J:158973 )

• cultured primary neurons cannot be myelinated by Rat Schwann cells unlike similarly treated neurons from heterozygous mice

demyelination ( J:158973 , J:166449 )

• in the sciatic nerve at P12 that is less severe than in Lgi4^clp homozygotes (J:158973)

• of peripheral nerves (J:166449)

growth/size/body

decreased body weight ( J:166449 )

• at P1 and P12