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Phenotypes Associated with This Genotype
Genotype
MGI:4441203
Allelic
Composition
Lmx1btm1Rjo/Lmx1btm1Zfc
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1btm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1btm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• mice exhibit dorsal-to-ventral transformation of skeletal tissues compared with wild-type mice
• mice exhibit partial duplication of sesamoid bones at the metacarpophalangeal joint compared with wild-type mice
• mice exhibit dorsal sesamoid bones and dorsal cartilagenious protrusion of the metacarpal unlike in wild-type mice
• mice exhibit reduced tips of the metacarpals compared with wild-type mice
• the scaphoid, falciform, and pisiform are duplicated in a dorsal position unlike in wild-type mice
• mice exhibit dorsal-to-ventral transformation of tendon tissues compared with wild-type mice
• the dorsal tendon is round unlike in wild-type mice
• the dorsal flexure at the ankle is absent

muscle
• mice exhibit dorsal-to-ventral transformation of tendon tissues compared with wild-type mice
• the dorsal tendon is round unlike in wild-type mice

limbs/digits/tail
• mice exhibit less hair on the dorsal skin of the paw that resembles a footpad unlike in wild-type mice
• mice exhibit partial duplication of sesamoid bones at the metacarpophalangeal joint compared with wild-type mice
• mice exhibit dorsal sesamoid bones and dorsal cartilagenious protrusion of the metacarpal unlike in wild-type mice
• mice exhibit reduced tips of the metacarpals compared with wild-type mice
• the scaphoid, falciform, and pisiform are duplicated in a dorsal position unlike in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory