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Phenotypes Associated with This Genotype
Genotype
MGI:4441061
Allelic
Composition
Tubb3tm1.1Ece/Tubb3tm1.1Ece
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tubb3tm1.1Ece mutation (0 available); any Tubb3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• at E11.5 to E12, guidance and branching of cranial nerves is defective compared to in wild-type mice
• mice exhibit defective guidance of commissural axons and cranial nerves compared with wild-type mice
• mice exhibit defective guidance of commissural axons and cranial nerves compared with wild-type mice
• 2 of 5 mice exhibit thin corpus callosum compared with wild-type mice
• 1 of 5 mice exhibit thick corpus callosum compared with wild-type mice
• in 2 of 5 mice
• mice exhibit a thinning and/or absent midline crossing of the anterior commissure throughout its anterior-posterior axis compared with wild-type mice
• the anterior-posterior axis appears tortuous and often has aberrant fiber projections at the midline unlike in wild-type mice
• asymmetric in some mice
• at E11.5 to E12, guidance and branching of cranial nerves is defective compared to in wild-type mice
• the oculomotor nerve fails to reach the correct muscle anlage and instead projected towards the position of the superior oblique unlike in wild-type mice
• the trigeminal nerve fails to grow and branch properly unlike in wild-type mice
• trochlear nerve growth is often stalled unlike in wild-type mice

respiratory system
• mice fail to breath normally at birth

cellular
• at E11.5 to E12, guidance and branching of cranial nerves is defective compared to in wild-type mice
• mice exhibit defective guidance of commissural axons and cranial nerves compared with wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory