Mouse Genome Informatics
hm
    Tubb3tm1.1Ece/Tubb3tm1.1Ece
involves: 129S/SvEv * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging

nervous system
• at E11.5 to E12, guidance and branching of cranial nerves is defective compared to in wild-type mice
• mice exhibit defective guidance of commissural axons and cranial nerves compared with wild-type mice
• mice exhibit defective guidance of commissural axons and cranial nerves compared with wild-type mice
• 2 of 5 mice exhibit thin corpus callosum compared with wild-type mice
• 1 of 5 mice exhibit thick corpus callosum compared with wild-type mice
• in 2 of 5 mice
• mice exhibit a thinning and/or absent midline crossing of the anterior commissure throughout its anterior-posterior axis compared with wild-type mice
• the anterior-posterior axis appears tortuous and often has aberrant fiber projections at the midline unlike in wild-type mice
• asymmetric in some mice
• at E11.5 to E12, guidance and branching of cranial nerves is defective compared to in wild-type mice
• the oculomotor nerve fails to reach the correct muscle anlage and instead projected towards the position of the superior oblique unlike in wild-type mice
• the trigeminal nerve fails to grow and branch properly unlike in wild-type mice
• trochlear nerve growth is often stalled unlike in wild-type mice

respiratory system
• mice fail to breath normally at birth

cellular
• at E11.5 to E12, guidance and branching of cranial nerves is defective compared to in wild-type mice
• mice exhibit defective guidance of commissural axons and cranial nerves compared with wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Fibrosis of Extraocular Muscles, Congenital, 3a, with or without Extraocular Involvement; CFEOM3A 600638 J:158992